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The role of Tc-99m polyclonal human immunoglobulin G scintigraphy in Graves' ophthalmopathy.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ortapamuk, Hulya Hoşal, Banu Melek Naldöken, Seniha |
| Copyright Year | 2002 |
| Abstract | OBJECTIVE The aim of this study was to clarify whether Tc-99m HIG (Polyclonal Human Immunoglobulin G) can image and determine the severity of orbital involvement in patients with Graves' ophthalmopathy. MATERIALS AND METHODS Twenty-six patients between 19 and 56 years old with Graves' ophthalmopathy were examined. All patients received approximately 370 MBq Tc-99m HIG by i.v. injection. Planar and SPECT examination were performed 4 hours after the injection. Visual and semiquantitative evaluations were performed for both orbits by two independent observers, RESULTS Clinically active ophthalmopathy patients had noticeably increased orbital accumulation of Tc-99m HIG. In patients with inactive disease, and 14 of 19 had no uptake, whereas 5 patients had orbital radioactivity accumulation. The duration of Graves' ophthalmopathy did not correlate with the presence of active ophthalmopathy and Tc-99m HIG grade. There was no correlation between clinical classification and clinical activity (r = 278). There was a good correlation between clinical activity and the radioactivity grade with r = 0.666 (p = 0.01). The clinical classification closely correlated with Tc-99m HIG grade (r = 0.423, p = 0.05). CONCLUSION Tc-99m HIG scan can clearly identified clinically active patients, and subclinicial inflammation can be shown by this scintigraphic evaluation. The current preliminary results suggested that Tc-99m HIG SPECT might be useful for the assessment of disease activity in Graves' ophthalmopathy. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.jsnm.org/files/paper/anm/ams167/ANM16-7-04.pdf?origin=publication_detail |
| PubMed reference number | 12508836v1 |
| Volume Number | 16 |
| Issue Number | 7 |
| Journal | Annals of nuclear medicine |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Disorder of eye Evaluation Graves Disease Megabecquerel Ocular orbit Patients Physical Inactivity Radioactivity Radionuclide Imaging Sacroiliitis Technetium Tc 99m Medronate Technetium Tc 99m Sestamibi Thyroid associated opthalmopathies observers |
| Content Type | Text |
| Resource Type | Article |
