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Molecularly imprinted polymer-capped nitrogen-doped graphene quantum dots as a novel chemiluminescence sensor for selective and sensitive determination of doxorubicin
| Content Provider | Semantic Scholar |
|---|---|
| Author | Amjadi, Mohammad Jalili, Roghayeh |
| Copyright Year | 2016 |
| Abstract | In this work, molecularly imprinted polymer-capped nitrogen-doped graphene quantum dots (MIP@NGQDs) were prepared via a simple sol–gel process and used for recognition of the anti-cancer drug, doxorubicin. Strong chemiluminescence (CL) emission was observed when potassium permanganate was injected into the solution of MIP@NGQDs. At the same time, in the presence of doxorubicin the CL intensity was significantly quenched and this was exploited to develop a CL detection scheme for this drug. The mechanism of the MIP@NGQDs/KMnO4 CL system was investigated by recording UV-Vis, fluorescence and CL spectra. Under the optimal conditions, the relative CL intensity linearly decreased with the concentration of doxorubicin in the range of 20–260 μg L−1. The limit of detection was 4.7 μg L−1. The method was applied to the determination of therapeutic levels of doxorubicin in spiked serum samples with satisfactory results. |
| Starting Page | 86736 |
| Ending Page | 86743 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C6RA18184H |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/c6/ra/c6ra18184h/c6ra18184h1.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/C6RA18184H |
| Volume Number | 6 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
