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Author ' s personal copy

Content Provider	Semantic Scholar
Author	Ibarraa, Alvin Baia, Naisheng Bilya, Antoine Casesb, Julien Rollerb, Marc Sangc, Shengmin
Copyright Year	2011
Abstract	Purpose: The aim of this study was to determine whether a Fraxinus excelsior L. seed extract, FraxiPureTM (0.5% in the diet), limits weight gain and hyperglycemia in mice. In a previous report, we identified several secoiridoids in FraxiPureTM, some of which activated peroxisome proliferator-activated receptor alpha (PPAR ) in vitro and inhibited the differentiation of 3T3-L1 preadipocyte cells. In a separate study, FraxiPureTM reduced glycemia in healthy volunteers, following an oral glucose tolerance test. These findings suggest that FraxiPureTM has antiobesity and antihyperglycemia effects. Materials and methods: FraxiPureTM was tested in mice that were fed a high-fat diet over 16 weeks and compared with low-fat and high-fat diet controls. Weight gain, omental and retroperitoneal fat, fasting blood glucose, and fasting blood insulin were measured. Results: FraxiPureTM reduced gains in body weight by 32.30% (p < 0.05), omental fat by 17.92%, and retroperitoneal fat by 17.78%. FraxiPureTM also lowered fasting blood glucose levels by 76.52% (p < 0.001) and plasma insulin levels by 53.43% (p < 0.05) after 16 weeks. Moreover, FraxiPureTM lowered liver weight gains by 63.62% (p < 0.05) and the incidence of fatty livers by 66.67%. Conclusions: Our novel results demonstrate the antiobesity effects of chronic administration of an F. excelsior seed extract and confirm its ability to regulate glycemia and insulinemia. In addition, this extract, which is rich in secoiridoid glucosides, protects against obesity-related liver steatosis. © 2010 Elsevier GmbH. All rights reserved.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://lyush.ntyxc.servertrust.com/v/vspfiles/bps_pdfs/nanogluco/07hyperglycemia%20-Ibarra-Phytomedicine-2011.pdf
Language	English
Access Restriction	Open
Content Type	Text

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