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Extraordinarily wide genomic impact of a selective sweep associated with the evolution of sex 1 ratio distorter suppression 2 3 Running head : Genomic impact of intense selection in a butterfly 4 5
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hornett, Ea Wedell Hurst |
| Copyright Year | 2014 |
| Abstract | 21. CC-BY-NC-ND 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not. Abstract 22 Symbionts that distort their host's sex ratio by favouring the production and survival of females are 23 common in arthropods. Their presence produces intense Fisherian selection to return the sex ratio to 24 parity, typified by the rapid spread of host 'suppressor' loci that restore male survival/development. 25 In this study, we investigated the genomic impact of a selective event of this kind in the butterfly 26 Hypolimnas bolina. Through linkage mapping we first identified a genomic region that was 27 necessary for males to survive Wolbachia-induced killing. We then investigated the genomic impact 28 of the rapid spread of suppression that converted the Samoan population of this butterfly from a 29 100:1 female-biased sex ratio in 2001, to a 1:1 sex ratio by 2006. Models of this process revealed 30 the potential for a chromosome-wide selective sweep. To measure the impact directly, the pattern of 31 genetic variation before and after the episode of selection was compared. Significant changes in 32 allele frequencies were observed over a 25cM region surrounding the suppressor locus, alongside 33 generation of linkage disequilibrium. The presence of novel allelic variants in 2006 suggests that 34 the suppressor was introduced via immigration rather than through de novo mutation. In addition, 35 further sampling in 2010 indicated that many of the introduced variants were lost or had reduced in 36 frequency since 2006. We hypothesise that this loss may have resulted from a period of purifying 37 selection-removing deleterious material that introgressed during the initial sweep. Our 38 observations of the impact of suppression of sex ratio distorting activity reveal an extraordinarily 39 wide genomic imprint, reflecting its status as one of the strongest selective forces in nature. 40 41 42. CC-BY-NC-ND 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not. Author summary 43 The sex ratio produced by an individual can be an evolutionary battleground. In many arthropod 44 species, maternally inherited microbes selectively kill male hosts, and the host may then in turn 45 evolve strategies to restore the production or survival of males. When males are rare, the intensity 46 of selection on the host may be extreme. We recently observed one such episode, … |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.biorxiv.org/content/biorxiv/early/2014/07/09/006981.full.pdf |
| Alternate Webpage(s) | http://biorxiv.org/content/biorxiv/early/2014/07/09/006981.full.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
