Efficacy of d-CPPene, a competitive N-methyl-d-aspartate antagonist in focal cerebral ischemia in the rat

Content Provider	Semantic Scholar
Author	Park, Chun Kun Mcculloch, J. Kang, Joon Ki Choi, Chang Rak
Copyright Year	1992
Abstract	The effect of a novel and potent competitive N-methyl-D-aspartate (NMDA) antagonist D-(E)-4-(3-phosphonoprop-2-enyl)piperazine-2-carboxylic acid (D-CPPene) upon ischemic brain damage has been examined in a rat model of focal cerebral ischemia. Focal cerebral ischemia was produced by permanent occlusion of the left middle cerebral artery (MCA). The animals were sacrificed 24 h after MCA occlusion and the amount of ischemic brain damage was assessed at 8 predetermined coronal planes. Pretreatment with D-CPPene (1.5, 4.5 or 15 mg/kg, i.v.), initiated 15 min prior to MCA occlusion (followed by constant infusion at 1, 3 or 10 mg/kg/h), produced dose-dependent reductions in the volumes of infarction; the dose of 4.5 mg/kg being the most effective (reduced by 37%; P < 0.01). These results indicate that systemic administration of the competitive NMDA antagonist D-CPPene has neuroprotective effects in a model of focal cerebral ischemia and define the dose dependency of its neuroprotective effects.
Starting Page	41
Ending Page	44
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/0304-3940(92)90770-8
PubMed reference number	1480321
Journal	Medline
Volume Number	147
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0304394092907708
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0304394092907708?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0304-3940%2892%2990770-8
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article