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Function of CikA in the cyanobacterial circadian system: the pseudo-receiver domain of CikA regulates the circadian input pathway
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhang, Xiaofan |
| Copyright Year | 2006 |
| Abstract | Function of CikA in the Cyanobacterial Circadian System: The pseudo-Receiver Domain of CikA Regulates the Circadian Input Pathway. (August 2006) Xiaofan Zhang, B.S., East China Normal University; M.S., Shandong Agricultural University Chair of Advisory Committee: Dr. Susan S. Golden The circadian input kinase gene (cikA) was first identified from a Tn5 mutant of Synechococcus elongatus PCC 7942. A cikA null strain shows a striking phenotype related to circadian gene regulation: all sampled loci show a shortened circadian period and reduced amplitude of oscillation and a failure to exhibit a wild-type resetting of the phase of the rhythm after an environmental signal. This global defect in response to the environment suggests a key role for CikA in the circadian input pathways. Bioinformatics results classify CikA as a divergent member of the bacteriophytochrome family, suggesting a role in light signal transduction. In vitro analysis previously showed that CikA is a bona fide histidine protein kinase (HPK), and its kinase activity is regulated by the presence of other domains. Its own pseudo-receiver (PsR) domain is not the cognate receiver domain of its kinase HPK domain, and its GAF domain does not likely bind a bilin chromophore as do photoreceptive phytochromes. Recent results suggested that CikA may function as a redox-sensor. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oaktrust.library.tamu.edu/bitstream/handle/1969.1/4261/etd-tamu-2006B-MBIO-ZHANG.pdf?isAllowed=y&sequence=1 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
