NDLI: Chelidonium majus L. extract induces apoptosis through caspase activity via MAPK-independent NF-κB signaling in human epidermoid carcinoma A431 cells.

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Chelidonium majus L. extract induces apoptosis through caspase activity via MAPK-independent NF-κB signaling in human epidermoid carcinoma A431 cells.

Content Provider	Semantic Scholar
Author	Park, Seung-Won Kim, Seong Ryul Kim, Youngchul Lee, Jang-Hoon Woo, Hong-Jung Yoon, Yeo-Kwang Kim, Young Il
Copyright Year	2015
Abstract	Chelidonium majus L. (C. majus L.) is known to possess certain biological properties such as anti-inflammatory, antimicrobial, antiviral and antitumor activities. We investigated the effects of C. majus L. extract on human epidermoid carcinoma A431 cells through multiple mechanisms, including induction of cell cycle arrest, activation of the caspase-dependent pathway, blocking of nuclear factor-κB (NF-κB) activation and involvement in the mitogen-activated protein kinase (MAPK) pathway. C. majus L. inhibited the proliferation of A431 cells in a dose- and time-dependent manner, increased the percentage of apoptotic cells, significantly decreased the mRNA levels of cyclin D1, Bcl-2, Mcl-1 and survivin and increased p21 and Bax expression. Exposure of A431 cells to C. majus L. extract enhanced the activities of caspase-3 and caspase-9, while co-treatment with C. majus L., the pan-caspase inhibitor Z-VAD-FMK and the caspase-3 inhibitor Z-DEVE-FMK increased the proliferation of A431 cells. C. majus L. extract not only inhibited NF-κB activation, but it also activated p38 MAPK and MEK/ERK signaling. Taken together, these results demonstrate that C. majus L. extract inhibits the proliferation of human epidermoid carcinoma A431 cells by inducing apoptosis through caspase activation and NF-κB inhibition via MAPK-independent pathway.
File Format	PDF HTM / HTML
DOI	10.3892/or.2014.3566
PubMed reference number	25354169
Journal	Medline
Volume Number	33
Issue Number	1
Journal	Oncology reports
Alternate Webpage(s)	https://www.spandidos-publications.com/or/33/1/419/download
Alternate Webpage(s)	https://doi.org/10.3892/or.2014.3566
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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