NDLI: Ceramide-coated balloon catheters limit neointimal hyperplasia after stretch injury in carotid arteries.

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Ceramide-coated balloon catheters limit neointimal hyperplasia after stretch injury in carotid arteries.

Content Provider	Semantic Scholar
Author	Charles, Rhonda Sandirasegarane, Lakshman Yun, Jae Woong Bourbon, Nicole A. Wilson, Ron Rothstein, Raymond P. Levison, Steven W. Kester, Mark
Copyright Year	2000
Abstract	Neointimal hyperplasia at the site of surgical intervention is a common and deleterious complication of surgery for cardiovascular diseases. We hypothesized that direct delivery of a cell-permeable growth-arresting lipid via the balloon tip of an embolectomy catheter would limit neointimal hyperplasia after stretch injury. We have previously demonstrated that sphingolipid-derived ceramide arrested the growth of smooth muscle cell pericytes in vitro. Here, we show that ceramide-coated balloon catheters significantly reduced neointimal hyperplasia induced by balloon angioplasty in rabbit carotid arteries in vivo. This ceramide treatment decreased the number of vascular smooth muscle cells entering the cell cycle without inducing apoptosis. In situ autoradiographic studies demonstrated that inflating the balloon catheter forced cell-permeable ceramide into the intimal and medial layers of the artery. Intercalation of ceramide into vascular smooth muscle cells correlated with rapid inhibition of trauma-associated phosphorylation of extracellular signal-regulated kinase and protein kinase B. These studies demonstrate the utility of cell-permeable ceramide as a novel therapy for reducing neointimal hyperplasia after balloon angioplasty.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://circres.ahajournals.org/content/circresaha/87/4/282.full.pdf?download=true
PubMed reference number	10948061v1
Volume Number	87
Issue Number	4
Journal	Circulation research
Language	English
Access Restriction	Open
Subject Keyword	Angioplasty, Balloon Angioplasty, Balloon, Coronary Apoptosis Arterial system Cardiac Arrest Cardiovascular Diseases Carotid Arteries Carotid Body Paraganglioma Cell Cycle Ceramides Congenital adrenal hyperplasia Embolectomy Muscle Cells Muscle, Smooth, Vascular Myocytes, Smooth Muscle Pericytes Protein Kinases Smooth muscle (tissue) Sphingolipids Wounds and Injuries anatomical layer
Content Type	Text
Resource Type	Article

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