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Celecoxib exerts antitumor effects in canine mammary tumor cells via COX‑2‑independent mechanisms.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tamura, Dai Saito, Teruyoshi Murata, Kanae Kawashima, Masafumi Asano, Ryuji |
| Copyright Year | 2015 |
| Abstract | Celecoxib plays antitumor roles via multiple mechanisms in a variety of human cancers. The aim of this study was to clarify the mechanism of action of celecoxib in canine mammary tumors. We examined the antitumor effects of celecoxib in AZACB canine mammary tumor cells expressing low levels of cyclooxygenase‑2 (COX‑2) to minimize the effect of COX‑2 on its activity. Our data revealed that celecoxib inhibited cell proliferation mainly via COX‑2‑independent mechanisms. Specifically, celecoxib decreased the proportion of cells in S phase and increased G2/M arrest, which was associated with increased expression of the cyclin‑dependent kinase inhibitors (CDKIs) p21 and p27. In addition, treatment with celecoxib downregulated COX‑2 expression, and induced apoptosis via both the intrinsic and extrinsic pathways. These findings suggest that celecoxib might be a useful agent for the treatment of canine mammary tumors, regardless of COX‑2 expression. In the future, it might be possible to use a combination of celecoxib and other antitumor agents to treat canine mammary tumors. |
| File Format | PDF HTM / HTML |
| DOI | 10.3892/ijo.2015.2820 |
| PubMed reference number | 25571853 |
| Journal | Medline |
| Volume Number | 46 |
| Issue Number | 3 |
| Alternate Webpage(s) | https://www.spandidos-publications.com/ijo/46/3/1393/download |
| Alternate Webpage(s) | https://doi.org/10.3892/ijo.2015.2820 |
| Journal | International journal of oncology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
