NDLI: Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study.

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Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study.

Content Provider	Semantic Scholar
Author	Raskind, Murray Peskind, Elaine Kanter, Evan D. Petrie, Eric C. Radant, Allen Thompson, Charles E. Dobie, Dorcas J. Hoff, David J. Rein, Rebekah J. Straits-Tröster, Kristy Thomas, Ronald H. G. McFall, Miles M.
Copyright Year	2003
Abstract	OBJECTIVE Prazosin is a centrally active alpha(1) adrenergic antagonist. The authors' goal was to evaluate prazosin efficacy for nightmares, sleep disturbance, and overall posttraumatic stress disorder (PTSD) in combat veterans. METHOD Ten Vietnam combat veterans with chronic PTSD and severe trauma-related nightmares each received prazosin and placebo in a 20-week double-blind crossover protocol. RESULTS Prazosin (mean dose=9.5 mg/day at bedtime, SD=0.5) was superior to placebo for the three primary outcome measures: scores on the 1) recurrent distressing dreams item and the 2) difficulty falling/staying asleep item of the Clinician-Administered PTSD Scale and 3) change in overall PTSD severity and functional status according to the Clinical Global Impression of change. Total score and symptom cluster scores for reexperiencing, avoidance/numbing, and hyperarousal on the Clinician-Administered PTSD Scale also were significantly more improved in the prazosin condition, and prazosin was well tolerated. CONCLUSIONS These data support the efficacy of prazosin for nightmares, sleep disturbance, and other PTSD symptoms.
File Format	PDF HTM / HTML
DOI	10.1176/appi.ajp.160.2.371
Alternate Webpage(s)	http://psychsurfer.com/for_clinicians/PTSD_files/Reduction%20of%20Nightmares%20and%20Other%20PTSD%20Symptoms%20in%20Combat%20Veterans%20by%20Prazosin-%20A%20Placebo-Controlled%20Study.pdf
Alternate Webpage(s)	http://www.nctsnet.org/nctsn_assets/Articles/119.pdf
PubMed reference number	12562588
Alternate Webpage(s)	https://doi.org/10.1176/appi.ajp.160.2.371
Journal	Medline
Volume Number	160
Issue Number	2
Journal	The American journal of psychiatry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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