Melatonin rhythms in renal transplant recipients with sleep-wake disturbances.

Content Provider	Semantic Scholar
Author	Burkhalter, Hanna Geest, Sabina De Wirz-Justice, Anna Cajochen, Christian
Copyright Year	2016
Abstract	We assessed salivary melatonin levels in renal transplant (RTx) recipients who participated in a randomised, multicentre wait-list controlled trial on the effect of bright light therapy on their sleep and circadian rhythms. A large proportion of RTx recipients in our cohort had unexpectedly low melatonin values, which precluded calculation of the dim-light melatonin onset (DLMO) as a circadian marker. Thus, the aim of this post hoc analysis was to describe the melatonin profile of home-dwelling RTx recipients diagnosed with sleep-wake disturbances (SWDs). The participants were characterised by means of sleep questionnaires, validated psychometric instruments [Pittsburgh sleep quality Index (PSQI), Epworth sleepiness scale (ESS), Morningness-Eveningness Questionnaire (MEQ) and Depression, Anxiety and Stress Scale (DASS)] in addition to melatonin assay in saliva. Data were analysed with descriptive statistics and group comparisons made with appropriate post hoc tests. RTx recipients [n = 29 (aged 54.83 ± 13.73, transplanted 10.62 ± 6.84 years ago)] were retrospectively grouped into two groups: RTx recipients whose dim light melatonin onset (DLMO) could be calculated (n = 11) and those whose DLMO could not be calculated (n = 18). RTx recipients having a measurable DLMO had a number of differences from those without DLMO: they were younger [46.4 ± 14.9 compared to 60.0 ± 10.3 (p = .007)], had higher haemoglobin values [135.36 ± 12.01 versus 122.82 ± 11.56 (p = .01)], less anxiety [4 (0;8) versus 12 (6.5;14) (p = .021)] and a better overall sense of coherence [SOC Score: 71.09 ± 12.78 versus 56.28 ± 15.48 (p = 0.013)]. These results suggest that RTx recipients whose DLMO could be calculated have less health impairments, underlying the relevance of a stable circadian system.
Starting Page	781
Ending Page	788
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.chronobiology.ch/wp-content/uploads/2016/06/Melatonin-rhythms-in-renal-transplant-recipients-with-sleep-wake-disturbances.pdf
PubMed reference number	27101434v1
Alternate Webpage(s)	https://doi.org/10.3109/07420528.2016.1169192
DOI	10.3109/07420528.2016.1169192
Journal	Chronobiology international
Volume Number	33
Issue Number	7
Language	English
Access Restriction	Open
Subject Keyword	Adrenergic beta-Agonists Adrenergic beta-Antagonists Anxiety Disorders Atenolol Bisoprolol Classes - encounter Depressive disorder Description Epworth Sleepiness Scale Questionnaire Forty Nine Hemoglobin Impaired health Instrument - device Kidney Transplantation Melatonin Photophobia Pittsburgh Sleep Quality Index Power (Psychology) Propranolol SBDS gene Sleep Disorders Sleep Disorders, Circadian Rhythm Sleep Wake Disorders Somnolence Statistical Test Transplant Recipients age differences carvedilol nebivolol resiniferatoxin
Content Type	Text
Resource Type	Article