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Effect of intraperitoneal and intrahippocampal (CA1) 2-chloroadenosine in amygdaloid kindled rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | Pourgholami, Mohammad Hossein Mirnajafi-Zadeh, Javad Behzadi, Jila |
| Copyright Year | 1997 |
| Abstract | Effects of intraperitoneal and intrahippocampal 2-chloroadenosine and caffeine were examined in fully kindled amygdaloid rats. Intraperitoneal administration of 2-chloroadenosine (5 and 10 mg/kg) decreased afterdischarge duration, stage 5 seizure duration and prolonged time taken to reach stage 4 seizure. Only the 10 mg/kg dose induced a significant reduction in seizure stage. Intraperitoneal administration of caffeine (50 mg/kg) increased both afterdischarge duration and stage 5 seizure duration but did not significantly alter other parameters. Intrahippocampal microinfusion of 2-chloroadenosine (1 mM) or caffeine (2 mM) did not alter any of the measured seizure parameters. Intraperitoneal but not intrahippocampal pretreatment of animals with caffeine (50 mg/kg and 2 mM, respectively) blocked the anticonvulsant effects induced by intraperitoneal administration of 2-chloroadenosine. It may therefore be concluded that the adenosine A1 receptors of the CA1 region of the hippocampus do not play a role in mediating the anticonvulsant effects of intraperitoneally administered 2-chloroadenosine in amygdaloid kindled rats. |
| Starting Page | 259 |
| Ending Page | 264 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0006-8993(96)01406-0 |
| PubMed reference number | 9099813 |
| Journal | Medline |
| Volume Number | 751 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0006899396014060 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0006899396014060?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0006-8993%2896%2901406-0 |
| Journal | Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
