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Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Schwenger, Peter Bellosta, Paola Vietor, Ilja Basilico, Claudio Skolnik, Edward Y. Vilček, Jan |
| Copyright Year | 1997 |
| Abstract | In a previous study, we demonstrated that sodium salicylate (NaSal) selectively inhibits tumor necrosis factor (TNF)-induced activation of the p42 and p44 mitogen-activated protein kinases (MAPKs) (known as extracellular signal-regulated kinases). Here we show that in normal human FS-4 fibroblasts NaSal inhibits TNF-induced activation of another member of the MAPK family, the c-Jun N-terminal kinase/stress-activated protein kinase. c-Jun N-terminal kinase activation induced by interleukin 1 or epidermal growth factor was less strongly inhibited by NaSal. Unexpectedly, treatment of FS-4 cells with NaSal alone produced a strong activation of p38 MAPK and cell death by apoptosis. NaSal-induced apoptosis was blocked by the selective p38 MAPK inhibitor SB-203580, indicating that p38 MAPK serves as a mediator of NaSal-induced apoptosis in human fibroblasts. Activation of p38 MAPK and the resulting induction of apoptosis may be important in the demonstrated antineoplastic actions of nonsteroidal anti-inflammatory drugs. |
| File Format | PDF HTM / HTML |
| DOI | 10.1073/pnas.94.7.2869 |
| PubMed reference number | 9096313 |
| Journal | Medline |
| Volume Number | 94 |
| Issue Number | 7 |
| Alternate Webpage(s) | http://www.pnas.org/content/94/7/2869.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.1073/pnas.94.7.2869 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
