Determination of Candesartan Cilexetil in Tablets by Spectrofluorimetry

Content Provider	Semantic Scholar
Author	Sakur, Amir Alhaj Fael, Hanan
Copyright Year	2010
Abstract	A Simple, accurate, and highly sensitive spectrofluorimetric method is presented for the determination of candesartan cilexetil in bulk and tablets. The proposed method is based on direct measurement of candesartan cilexetil fluorescence intensity. The excitation and emission wavelengths were 260 nm and 381 nm, respectively. The method was linear over the concentration range of 3.00 – 288.60 ng/ml. The limit of detection was 0.25 ng/ml, and the limit of quantitation was 0.77 ng/ml. In order to validate the method the results were compared with those obtained by a high performance liquid chromatography method. The proposed method was successfully applied to the analysis of candesartan cilexetil in pure form and tablets with good precision and accuracy compared to the reported method as revealed by t- and F- tests. The method was shown to be highly specific in the presence of hydrochlorothiazide which is commonly combined with candesartan cilexetil in tablets.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.globalresearchonline.net/journalcontents/volume4issue1/Article%20012.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article