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Frequenza cardiaca, aterosclerosi e rottura di placca: aspetti fisiopatologici
| Content Provider | Semantic Scholar |
|---|---|
| Author | Folino, Antonio Franco Iliceto, Sabino |
| Copyright Year | 2006 |
| Abstract | Several epidemiological studies showed that an elevated heart rate is an independent risk factor for total and cardiovascular mortality. The explanation of these results is complex and is related to the role of heart rate in different pathophysiological mechanisms. First of all, elevated heart rate is a negative factor for cardiac performance by a reduction of heart cycle and the consequent decrease of myocardial perfusion, and by a simultaneous increase of oxygen consumption. Moreover, heart rate contributes as a modulating factor on the different mechanical forces applied on the artery. These are mainly related to two hemodynamic components, arterial blood pressure and blood viscosity. The first induces compressive and strain forces, whereas the second generates a shear stress on endothelial surface, not only promoting the initial formation of the plaque and its progression, but also plaque disruption and the consequent artery thrombosis and occlusion. |
| Starting Page | 12 |
| Ending Page | 19 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Volume Number | 7 |
| Alternate Webpage(s) | http://www.giornaledicardiologia.it/allegati/00710_2006_07/fulltext/S1-7_2006%2003%2012S-19S.pdf |
| Alternate Webpage(s) | http://www.giornaledicardiologia.it/r.php?a=8105&f=allegati/00710_2006_07/fulltext/S1-7_2006+03+12S-19S.pdf&l=11101&v=710 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
