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Sex and the single cell: meiosis in yeast.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Roeder, G. Shirleen |
| Copyright Year | 1995 |
| Abstract | Recent studies of Saccharomyces cerevisiae have significantly advanced our understanding of the molecular mechanisms of meiotic chromosome behavior. Structural components of the synaptonemal complex have been identified and studies of mutants defective in synapsis have provided insight into the role of the synaptonemal complex in homolog pairing, genetic recombination, crossover interference, and meiotic chromosome segregation. There is compelling evidence that most or all meiotic recombination events initiate with double-strand breaks. Several intermediates in the double-strand break repair pathway have been characterized and mutants blocked at different steps in the pathway have been identified. With the application of genetic, molecular, cytological, and biochemical methods in a single organism, we can expect an increasingly comprehensive and unified view of the meiotic process. |
| Starting Page | 59 |
| Ending Page | 66 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.pnas.org/content/92/23/10450.full.pdf |
| PubMed reference number | 7479818v1 |
| Volume Number | 92 |
| Issue Number | 23 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Chromosome Pairing Double Strand Break Repair Meiosis Meiotic Recombination Molecular Genetics (discipline) Recombination, Genetic Saccharomyces cerevisiae Synaptonemal Complex meiotic chromosome segregation mutant |
| Content Type | Text |
| Resource Type | Article |
