NDLI: 13th Annual NIH SBIR/STTR Conference Poster Abstracts for Printing-June, 2011

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13th Annual NIH SBIR/STTR Conference Poster Abstracts for Printing-June, 2011

Content Provider	Semantic Scholar
Copyright Year	2011
Abstract	Methods: The Visulex® passive drug delivery system for ophthalmic usage features a fast swelling matrix with quick absorption and release that is suitable for both hydrophilic and hydrophobic drugs. It is easy to apply and remove, self-adheres to the eye during the application, and provides corneal protection. For these studies, the dimensions of the Visulex® applicator were altered to fit a mature New Zealand white rabbit (NZW), but all other features were kept the same as the Visulex® human applicator. All experiments were performed with NZW rabbits. Four formulations of DSP were tested. A Visulex® applicator loaded with each formulation was applied to the eye with the drug matrix in immediate contact with the conjunctiva/sclera for 5 to 20 min, and then the applicator was removed. For the drug distribution study, the rabbits were sacrificed immediately after device removal. The eye was dissected into seven tissue sections (i.e. anterior chamber, lens, retina-choroid, cornea, vitreous, conjunctiva, and sclera). The total amount of DSP in the tissues was determined by HPLC. For the safety study, the rabbits received weekly dosing for 12 applications. The eyes were examined daily with an indirect ophthalmoscope and graded based on a modified McDonald-Shadduck grading scale for discharge, conjunctival irritation, corneal defect, synechia, hypopion, anterior chamber flare, and vitreal opacity. At the end of the 12 weeks, the animals were sacrificed, the eyes collected, and histopathological examination performed.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://grants.nih.gov/grants/funding/SBIRConf2011/docs/Abstracts_for_printing.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Synopsis

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