NDLI: Effects of fasudil on hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats.

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Effects of fasudil on hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats.

Content Provider	Semantic Scholar
Author	Tian, X.-Y. Wang, D-W Li, Jingyi
Copyright Year	2014
Abstract	AIM The aim of this study was to investigate the effects of Rho kinase inhibitor-Fasudil on hypoxic pulmonary hypertension (HPH) and pulmonary vascular remodeling in rats. MATERIALS AND METHODS A total of 24 Sprague Dawley rats were evenly randomized into control, model and Fasudil intervention groups. Light and transmission electron microscopy were utilized to observe pulmonary vascular remodeling as well as ultrastructural changes in pulmonary arteriole endothelial cells. RESULTS The model group showed apparent pulmonary vascular remodeling, pulmonary arteriole endothelial cell injury, the proliferation and swelling of smooth muscle cells around, and the proliferation of collagen fibers. Fasudil intervention improved pulmonary vascular remodeling as well as relieved pulmonary arteriole endothelial cell injury and the proliferation of smooth muscle cells and collagen fibers. CONCLUSIONS Fasudil has preventive and reverse effects on HPH, pulmonary vascular remodeling, and pulmonary arteriole endothelial cell injury.
File Format	PDF HTM / HTML
PubMed reference number	24763873
Journal	Medline
Volume Number	18
Issue Number	7
Alternate Webpage(s)	http://www.europeanreview.org/wp/wp-content/uploads/959-964.pdf
Journal	European review for medical and pharmacological sciences
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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