NDLI: Effect of heptachlor on hepatic mitochondrial oxidative phosphorylation in rat.

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Effect of heptachlor on hepatic mitochondrial oxidative phosphorylation in rat.

Content Provider	Semantic Scholar
Author	Meguro, Toshinari Izushi, Fumio Ogata, Masana
Copyright Year	1990
Abstract	In a study of the hepatotoxicity of heptachlor (1,4,5,6,7,8,8-heptachlor 3a, 4,7,7 a-tetrahydro-4,7-methanoindene), a major compound of chlordane, the effect of heptachlor on the respiratory activity (oxidative phosphorylation and electron transport) of rat liver mitochondria was investigated. Heptachlor at a final concentration of 50 microM with succinate as substrate decreased the respiratory control index (RCI) due to a marked inhibition of state 3 respiration and a slight inhibition of state 4 respiration. One hundred microM heptachlor with succinate as substrate suppressed the states 3 and 4 respiration almost completely. On the other hand, heptachlor at a final concentration ranging from 50 to 100 microM with beta-hydroxybutylate (beta-HB) slightly decreased the RCI and decreased the RCI hardly at all with ascorbate plus N,N,N',N', -tetramethylphenylene diamine (TMPD) as substrate. Heptachlor at a concentration of 50 microM in the presence of succinate also decreased the ADP/O ratio of mitochondria. The mode of inhibition of succinate oxidation by heptachlor apparently is a noncompetitive inhibition, as shown by Lineweaver-Burk plot.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.jstage.jst.go.jp/article/indhealth1963/28/4/28_4_151/_pdf
PubMed reference number	2283323v1
Volume Number	28
Issue Number	4
Journal	Industrial health
Language	English
Access Restriction	Open
Subject Keyword	Acridine Orange Adenosine Diphosphate Ascorbate Chemical and Drug Induced Liver Injury Chlordan Diamines Electron Transport Heptachlor Mitochondria, Liver Mitochondrial Inheritance Oxidative Phosphorylation Succinates beta Thalassemia oxidation
Content Type	Text
Resource Type	Article

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