A comparison of the potency of the oxime HLö-7 and currently used oximes (HI-6, pralidoxime, obidoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods.

Content Provider	Semantic Scholar
Author	Kuča, Kamil Cabal, J. F. Tirado Kassa, Jiří Jun, Daniel Hrabinová, Martina
Copyright Year	2005
Abstract	(1) The efficacy of the oxime HLö7 and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. (2) Both H oximes (HLö-7, HI-6) were found to be more efficacious reactivators of sarin and VX-inhibited acetylcholinesterase than pralidoxime and obidoxime. On the other hand, their potency to reactivate tabun-inhibited acetylcholinesterase is very low and does not reach the reactivating efficacy of obidoxime. In the case of cyclosarin, the oxime HI-6 was only found to be able to sufficiently reactivate cyclosarin-inhibited acetylcholinesterase in vitro. (3) Thus, the oxime HLö-7 does not seem to be more efficacious reactivator of nerve agent-inhibited acetylcholinesterase than HI-6 according to in vitro evaluation of their reactivation potency and, therefore, it is not more suitable to be introduced for antidotal treatment of nerve agent-exposed people than HI-6.
File Format	PDF HTM / HTML
DOI	10.14712/18059694.2018.36
PubMed reference number	16259317
Journal	Medline
Volume Number	48
Issue Number	2
Alternate Webpage(s)	https://actamedica.lfhk.cuni.cz/media/pdf/18059694.2018.36.pdf
Alternate Webpage(s)	https://doi.org/10.14712/18059694.2018.36
Journal	Acta medica
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article