NDLI: Intact retinal tissue and retinal pigment epithelium identified within a coloboma by high-speed, ultrahigh-resolution optical coherence tomography.

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Intact retinal tissue and retinal pigment epithelium identified within a coloboma by high-speed, ultrahigh-resolution optical coherence tomography.

Content Provider	Semantic Scholar
Author	Judson, C. H. Vuong, Laurel N. Gorczyńska, Iwona Srinivasan, Vivek Jay Fujimoto, James G. Duker, Jay S.
Copyright Year	2011
Abstract	PURPOSE The purpose of this study was to report on a posterior segment coloboma manifesting unusual morphology as determined by high-speed, ultrahigh-resolution optical coherence tomography imaging. METHODS A 47-year-old woman with bilateral colobomas was evaluated by fundus examination and high-speed, ultrahigh-resolution optical coherence tomography imaging. RESULTS Imaging with high-speed, ultrahigh-resolution optical coherence tomography showed intact retinal pigment epithelium within the posterior segment coloboma. Most of the retinal layers seemed to continue into the coloboma, although they exhibited slight attenuation. The external limiting membrane was clearly visible continuing within the coloboma, suggesting that Müller cells and the inner segments of the photoreceptors were still present in this area. The junction between the inner and outer segments of the photoreceptors ended at the margin of the coloboma, which may be because of either photoreceptor disruption or a change in the orientation of the outer segments. CONCLUSION High-speed, ultrahigh-resolution optical coherence tomography imaging showed the presence of Müller cells and photoreceptor inner segments within a posterior segment coloboma. The retinal pigment epithelium was intact within the coloboma, representing an unusual morphology.
File Format	PDF HTM / HTML
DOI	10.1097/ICB.0b013e3181cafc49
PubMed reference number	21218127
Journal	Medline
Volume Number	5
Issue Number	1
Alternate Webpage(s)	http://bme.ucdavis.edu/srinivasanlab/files/2012/09/2011ColobomaRetina.pdf
Alternate Webpage(s)	https://doi.org/10.1097/ICB.0b013e3181cafc49
Journal	Retinal cases & brief reports
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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