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Clinical outcomes by geographic region for patients implanted with the zotarolimus-eluting stent.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lotan, Chaim Jain, Ajay Feres, Fausto Firszt, A. García, Alberto F. Rothman, Martin Terry |
| Copyright Year | 2011 |
| Abstract | BACKGROUND Differences between geographic regions in patient characteristics and outcomes, particularly for acute coronary syndromes, have been demonstrated in clinical trials. Clinical outcomes after percutaneous coronary interventions with the Zotarolimus-eluting stent in a real-world population were assessed over time. OBJECTIVES The influence of geographic location on clinical outcomes with the Zotarolimus-eluting stent was assessed in 3 regions: Asia Pacific, Europe, and Latin America. METHODS A total of 8,314 patients (6,572 Europe, 1,522 Asia Pacific, and 220 Latin America) were followed for 1 year; 2,116 of these (1,613, 316, and 187, respectively) were followed for 2 years. Patient and lesion characteristics, dual antiplatelet therapy, and clinical outcomes were compared between Latin America and the other regions. RESULTS Patients in Latin America had the highest proportions of risk factors and prior myocardial infarction. Dual antiplatelet therapy usage rapidly declined in Latin America, from 44.9% at 6 months to 22.5% at 1 year and 7.8% at 2 years (Europe: 87.4%, 61.5%, 19.7%; Asia Pacific: 82.4%, 67.0%, 45.7%). There were no significant differences between Latin America and Europe or Asia Pacific for any outcome at either time point. The incidence of Academic Research Consortium definite and probable stent thrombosis was low (<1.2%) among all patients at 1 year and 2 years. CONCLUSION Clinical outcomes were comparable between patients in Latin America and Europe, and Latin America and Asia Pacific, despite less favorable clinical subsets in Latin America, a higher risk profile, and markedly lower use of dual antiplatelet therapy over time. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.scielo.br/pdf/abc/2011nahead/en_aop02711.pdf |
| Alternate Webpage(s) | http://www.scielo.br/pdf/abc/v96n5/en_aop02711.pdf |
| Alternate Webpage(s) | http://www.scielo.br/pdf/abc/v96n5/aop02711.pdf |
| PubMed reference number | 21468534v1 |
| Volume Number | 96 |
| Issue Number | 5 |
| Journal | Arquivos brasileiros de cardiologia |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acute Coronary Syndrome Dermox Dual Implants Myocardial Infarction Patients Percutaneous Coronary Intervention Probability Stent Device Component Thrombosis latin language zotarolimus |
| Content Type | Text |
| Resource Type | Article |
