Demonstration of the deposition of hemosiderin in the kidneys of patients with paroxysmal nocturnal hemoglobinuria by magnetic resonance imaging.

Content Provider	Semantic Scholar
Author	Suzukawa, Kazumi Ninomiya, Haruhiko Mitsuhashi, Shigeaki Anno, Izumi Nagasawa, Toshihiko Abe, Toshi
Copyright Year	1993
Abstract	Hemosiderinuria caused by intravascular hemolysis is a characteristic clinical feature of an acquired hemolytic disorder, paroxysmal nocturnal hemoglobinuria (PNH). We examined the deposition of hemosiderin (iron) in the kidneys of 6 patients with PNH using magnetic resonance imaging (MRI). Three patients with autoimmune hemolytic anemia (AIHA), a hemolytic disorder showing extravascular hemolysis, served as controls. In five of the six patients with PNH, a characteristic T2-weighted MRI of the kidneys, suggesting the deposition of iron (hemosiderin) predominantly in the renal cortex, was obtained. Hemosiderin-deposition was not revealed in the kidneys of any of the patients with AIHA. We conclude that MRI is a sensitive means of detecting hemosiderin deposited in the renal cortex of patients with PNH and that this feature is considerably specific for diseases showing intravascular hemolysis, as represented by PNH.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.jstage.jst.go.jp/article/internalmedicine1992/32/9/32_9_686/_pdf/-char/en
PubMed reference number	8142671v1
Volume Number	32
Issue Number	9
Journal	Internal medicine
Language	English
Access Restriction	Open
Subject Keyword	Anemia, Hemolytic Autoimmune hemolytic anemia Hemolysis (disorder) Hemosiderin Measurement Hemosiderinuria Intravascular hemolysis Magnetic Resonance Imaging Paroxysmal nocturnal hemoglobinuria Patients Structure of cortex of kidney hemolytic disease
Content Type	Text
Resource Type	Article