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Changes in substance P and 5-HT binding in the spinal cord dorsal horn and lamina 10 after dorsolateral funiculus lesions
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bernau, Nicola A. Dawson, Susanne D. Kane, Lynn A. Pubols, Lillian M. |
| Copyright Year | 1993 |
| Abstract | The present study was undertaken to determine whether changes in receptor binding of substance P (SP) and 5-hydroxytryptamine (5-HT) occur in lumbar spinal cord laminae 2, 3, 4 and 10 following interruption of descending SP and 5-HT input. These transmitters and spinal cord regions have been implicated in nociceptive and visceral functions. Quantitative receptor binding autoradiography was used to assess the binding of 2 nM [3H]SP and 2 nM [3H]5-HT to lumbar spinal cord sections taken from normal rats and rats with unilateral thoracic dorsolateral funiculus (DLF) lesions. Postoperative survival times ranged from 1 to 28 days. Substance P binding was above normal in laminae 2 and 3 ipsilateral to the lesion and in contralateral lamina 2 at 1 day postoperatively (DPO), and declined thereafter, reaching below normal levels by 28 DPO. Substance P binding in lamina 10 was significantly above normal at 7 and 14 DPO, but not at 1 or 28 DPO. Binding of 5-HT was above normal at 7 DPO in lamina 2 ipsilateral to the lesion, lamina 3 contralaterally, and lamina 10 bilaterally. These increases were not sustained, however, and at 28 DPO 5-HT binding was significantly below normal in laminae 2-4 bilaterally. The bilateral effects seen in the present study are consistent with the bilaterality of descending thoracic DLF projections demonstrated by the Fink-Heimer method.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Starting Page | 106 |
| Ending Page | 114 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0006-8993(93)90460-5 |
| PubMed reference number | 7688641 |
| Journal | Medline |
| Volume Number | 613 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0006899393904605 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0006899393904605?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0006-8993%2893%2990460-5 |
| Journal | Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
