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Insulin resistance, body composition, and fat distribution in obese children with nonalcoholic fatty liver disease.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yang, Hye Ran Chang, Eun Jae |
| Copyright Year | 2016 |
| Abstract | BACKGROUND AND OBJECTIVES The aim of this study was to evaluate the influence of body composition, especially distribution of body fat, and insulin resistance on nonalcoholic fatty liver disease (NAFLD) in obese children. METHODS AND STUDY DESIGN One hundred obese children (66 boys, 34 girls) with (n=60) and without NAFLD (n=40) were assessed. Anthropometry, laboratory tests, abdominal ultrasonography, and dual energy x-ray absorption metry (DXA) were evaluated in all subjects. RESULTS Subject age and measurements of liver enzymes, γ- glutamyl transpeptidase (γGT), uric acid, high-density lipoprotein cholesterol, and insulin resistance were significantly different between the non-NAFLD group and NAFLD group. Body fat and trunk fat percentage were significantly different between the two groups (p<0.001 and p=0.003), whereas extremity fat percentage was not (p=0.683). Insulin resistance correlated significantly with body fat and trunk fat percentages, age, liver enzymes, γGT, and uric acid in obese children. Multiple logistic regression analysis indicated that insulin resistance and trunk fat percentage significantly affected the development of NAFLD in obese children. CONCLUSIONS Body fat, especially abdominal fat, influences the development of insulin resistance and subsequent NAFLD in obese children. Therefore, body composition measurement using DXA, in conjunction with biochemical tests, may be beneficial in evaluating obese children with NAFLD. |
| Starting Page | 557 |
| Ending Page | 562 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://apjcn.nhri.org.tw/server/APJCN/25/1/126.pdf |
| PubMed reference number | 26965771v1 |
| Alternate Webpage(s) | https://doi.org/10.6133/apjcn.2016.25.1.15 |
| DOI | 10.6133/apjcn.2016.25.1.15 |
| Journal | Asia Pacific journal of clinical nutrition |
| Volume Number | 25 |
| Issue Number | 1 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Abdominal Fat Adipose tissue Anthropometry Body Composition Cholesterol Dual Dual-Energy X-Ray Absorptiometry Fatty acid glycerol esters Gamma-glutamyl transferase Glutathione Insulin Resistance Laboratory Procedures Limb structure Lipoproteins Liver diseases Non-alcoholic Fatty Liver Disease Obesity Peptidyltransferase Plain x-ray Platelet Glycoprotein 4, human Uric Acid insulin, isophane |
| Content Type | Text |
| Resource Type | Article |
