NDLI: Abundant sequence divergence in the native Japanese cattle Mishima-Ushi (Bos taurus) detected using whole-genome sequencing.

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Abundant sequence divergence in the native Japanese cattle Mishima-Ushi (Bos taurus) detected using whole-genome sequencing.

Content Provider	Semantic Scholar
Author	Tsuda, Kaoru Kawahara-Miki, Ryouka Sano, Satoshi Imai, Misaki Noguchi, Tatsuo Inayoshi, Yousuke Kono, Tomohiro
Copyright Year	2013
Abstract	The native Japanese cattle Mishima-Ushi, a designated national natural treasure, are bred on a remote island, which has resulted in the conservation of their genealogy. We examined the genetic characteristics of 8 Mishima-Ushi individuals by using single nucleotide polymorphisms (SNPs), insertions, and deletions obtained by whole-genome sequencing. Mapping analysis with various criteria showed that predicted heterozygous SNPs were more prevalent than predicted homozygous SNPs in the exonic region, especially non-synonymous SNPs. From the identified 6.54 million polymorphisms, we found 400 non-synonymous SNPs in 313 genes specific to each of the 8 Mishima-Ushi individuals. Additionally, 3,170,833 polymorphisms were found between the 8 Mishima-Ushi individuals. Phylogenetic analysis confirmed that the Mishima-Ushi population diverged from another strain of Japanese cattle. This study provides a framework for further genetic studies of Mishima-Ushi and research on the function of SNP-containing genes as well as understanding the genetic relationship between the domestic and native Japanese cattle breeds.
File Format	PDF HTM / HTML
DOI	10.1016/j.ygeno.2013.08.002
PubMed reference number	23938316
Journal	Medline
Volume Number	102
Issue Number	4
Alternate Webpage(s)	http://www.y2wagyu.com/uploads/7/3/8/3/73835019/abundant_sequence_divergence_in_the_native_japanese_cattle.pdf
Alternate Webpage(s)	https://doi.org/10.1016/j.ygeno.2013.08.002
Journal	Genomics
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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