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Ablation of p120-catenin enhances invasion and metastasis of human lung cancer cells.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Liu, Yang Li, Qingshan Miao, Yuan Xu, Hong-Tao Dai, Shun-dong Wei, Qiang Dong, Qian-ze Dong, X. Zhao, Yue Zhao, Chen Wang, Enhua |
| Copyright Year | 2009 |
| Abstract | p120-catenin, a member of the Armadillo gene family, has emerged as both a master regulator of cadherin stability and an important modulator of small GTPase activities. Therefore, it plays novel roles in tumor malignant phenotype, such as invasion and metastasis. We have reported previously that abnormal expression of p120-catenin is associated with lymph node metastasis in lung squamous cell carcinomas (SCC) and adenocarcinomas. To investigate the role and possible mechanism of p120-catenin in lung cancer, we knocked down p120-catenin using small interfering RNA (siRNA). We found that ablation of p120-catenin reduced the levels of E-cadherin and beta-catenin proteins, as well as the mRNA of beta-catenin. Furthermore, p120-catenin depletion inactivated RhoA, but increased the activity of Cdc42 and Rac1, and promoted proliferation and the invasive ability of lung cancer cells both in vitro and in vivo. Our data reveal that p120-catenin gene knockdown enhances the metastasis of lung cancer cells, probably by either depressing cell-cell adhesion due to lower levels of E-cadherin and beta-catenin, or altering the activity of small GTPase, such as inactivation of RhoA and activation of Cdc42/Rac1. |
| Starting Page | 10002 |
| Ending Page | 10019 |
| Page Count | 18 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.cmu.edu.cn/curriculum/upload/200933115238636.pdf |
| PubMed reference number | 19154401v1 |
| Alternate Webpage(s) | https://doi.org/10.1111/j.1349-7006.2008.01067.x |
| DOI | 10.1111/j.1349-7006.2008.01067.x |
| Journal | Cancer science |
| Volume Number | 100 |
| Issue Number | 3 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Ablation Adenocarcinoma Anatomic Node Cadherins Carcinoma of lung Catenin Delta-1 Catenins Cell Adhesion Gene Knockdown Techniques Modulator Device Component Neoplasms Non-Small Cell Lung Carcinoma RNA, Small Interfering Squamous cell carcinoma Structure of parenchyma of lung beta catenin cancer cell cell-cell adhesion lymph node metastases lymph nodes rhoA GTP-Binding Protein |
| Content Type | Text |
| Resource Type | Article |
