NDLI: Differential stimulation of [3H]MK-801 binding to subpopulations of NMDA receptors

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Differential stimulation of [3H]MK-801 binding to subpopulations of NMDA receptors

Content Provider	Semantic Scholar
Author	Monaghan, Daniel T.
Copyright Year	1991
Abstract	The potency of L-glutamate in enhancing [3H]MK-801 binding to N-methyl-D-aspartate (NMDA) receptor ion channels was evaluated by quantitative autoradiography. In the presence of saturating concentrations of spermine, glycine and 20 microM D-2-amino-5-phosphonopentanoate (D-AP5), low concentrations of L-glutamate selectively increased [3H]MK-801 binding in the medial striatum and dorsal lateral septum. In comparison to these regions, EC50 values for L-glutamate stimulation of [3H]MK-801 binding were significantly higher in the cerebral cortex and thalamus. Regions displaying greater sensitivity to L-glutamate correlate to those regions where NMDA receptors are preferentially labelled by L-[3H]glutamate; regions less sensitive to L-glutamate correspond to regions selectively labelled by the NMDA antagonist [3H]CPP ([3H]3-((+) -2-carboxypiperazin-4-yl)-propyl-1-phosphonate). Since L-glutamate stimulation of [3H]MK-801 binding appears to reflect channel activation, these results suggest that it is possible to pharmacologically (or pathologically) activate anatomically-distinct subpopulations of NMDA receptors.
Starting Page	21
Ending Page	24
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/0304-3940(91)90183-T
PubMed reference number	1676144
Journal	Medline
Volume Number	122
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/030439409190183T
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/030439409190183T?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0304-3940%2891%2990183-T
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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