NDLI: Binding sites for calcitonin gene-related peptide in distinct areas of rat brain

Content Provider	Semantic Scholar
Author	Seifert, Hans Chesnut, Jon Souza, Errol B. De Rivier, Jean Vale, Wylie
Copyright Year	1985
Abstract	Calcitonin gene-related peptide (CGRP) binding sites were localized in rat brain and spinal cord by an in vitro labeling light microscopic technique using [125I]rCGRP as radioligand. Specific rCGRP binding with a dissociation constant (Kd) of 0.53 nM to membrane preparations from rat brain cortex was characterized. The presence and the selective distribution of specific high affinity CGRP binding sites in the central nervous system suggest a role for this recently predicted peptide as a neurotransmitter.
Starting Page	195
Ending Page	198
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/0006-8993(85)91116-3
PubMed reference number	3876866
Journal	Medline
Volume Number	346
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0006899385911163
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0006899385911163?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0006-8993%2885%2991116-3
Journal	Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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