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Neuropsychiatric predictors of progression from amnestic-mild cognitive impairment to Alzheimer's disease: the role of depression and apathy.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Palmer, Katie Iulio, Fulvia Di Varsi, Ambra Erika Gianni, Walter Sancesario, Giuseppe Caltagirone, Carlo Spalletta, Gianfranco |
| Copyright Year | 2010 |
| Abstract | The aim of the study is to evaluate whether depression or apathy in patients with amnestic-mild cognitive impairment (MCI) increases the risk of progressing to Alzheimer's disease (AD). We investigated 131 consecutive memory-clinic outpatients with newly-diagnosed amnestic-MCI (mean age 70.8, SD=6.5). Psychiatric disorders were diagnosed at baseline according to the criteria for depression and apathy in AD. Neuropsychiatric symptoms were assessed with the Neuropsychiatric Inventory (NPI). Follow-up examinations were conducted after six months and annually for four years. Neurologists diagnosed AD at follow-up using NINCDS-ADRDA criteria. Cox proportional hazard models with 95% confidence intervals were used to test the hypothesis that apathy or depression increases the risk of developing AD. At baseline, 36.6% amnestic-MCI patients had a diagnosis of depression and 10.7% had apathy. Patients with both amnestic-MCI and an apathy diagnosis had an almost sevenfold risk of AD progression compared to amnestic-MCI patients without apathy (HR=6.9; 2.3-20.6), after adjustment for age, gender, education, baseline global cognitive and functional status, and depression. Furthermore, the risk of developing AD increased 30% per point on the NPI apathy item (HR=1.3; 1.1-1.4). There was no increased risk of developing AD in amnestic-MCI patients with either a diagnosis or symptoms of depression. In conclusion, apathy, but not depression, predicts which patients with amnestic-MCI will progress to AD. Thus, apathy has an important impact on amnestic-MCI and should be considered a mixed cognitive/psychiatric disturbance related to ongoing AD neurodegeneration. |
| File Format | PDF HTM / HTML |
| DOI | 10.3233/JAD-2010-1352 |
| PubMed reference number | 20164594 |
| Journal | Medline |
| Volume Number | 20 |
| Issue Number | 1 |
| Alternate Webpage(s) | http://content.iospress.com/download/journal-of-alzheimers-disease/jad01352?id=journal-of-alzheimers-disease/jad01352 |
| Alternate Webpage(s) | https://doi.org/10.3233/JAD-2010-1352 |
| Journal | Journal of Alzheimer's disease : JAD |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
