NDLI: Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor.

Content Provider	Semantic Scholar
Author	Straight, Aaron F. Cheung, Amy M. Limouze, John Chen, Irene Westwood, Nick J. Sellers, James R. Mitchison, Timothy J.
Copyright Year	2003
Abstract	Completion of cell division during cytokinesis requires temporally and spatially regulated communication from the microtubule cytoskeleton to the actin cytoskeleton and the cell membrane. We identified a specific inhibitor of nonmuscle myosin II, blebbistatin, that inhibited contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Using blebbistatin and other drugs, we showed that exit from the cytokinetic phase of the cell cycle depends on ubiquitin-mediated proteolysis. Continuous signals from microtubules are required to maintain the position of the cleavage furrow, and these signals control the localization of myosin II independently of other furrow components.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://science.sciencemag.org/content/suppl/2003/03/12/299.5613.1743.DC1/Straight.pdf
PubMed reference number	12637748v1
Volume Number	299
Issue Number	5613
Journal	Science
Language	English
Access Restriction	Open
Subject Keyword	Cell division Cytokinesis of the fertilized ovum Cytoskeleton Microfilaments Mitosis Plasma membrane blebbistatin cell surface furrow cleavage furrow
Content Type	Text
Resource Type	Article

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