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rescent RNA alphabet : synthesis , photophysics and utility of isothiazole-derived purine nucleoside surrogates †
| Content Provider | Semantic Scholar |
|---|---|
| Author | Rovira, Alexander R. Fin, Andrea Tor, Yitzhak |
| Copyright Year | 2017 |
| Abstract | A series of emissive ribonucleoside purine mimics, all comprised of an isothiazolo[4,3-d]pyrimidine core, was prepared using a divergent pathway involving a key Thorpe–Ziegler cyclization. In addition to an adenosine and a guanosine mimic, analogues of the noncanonical xanthosine, isoguanosine, and 2-aminoadenosine were also synthesized and found to be emissive. Isothiazolo 2-aminoadenosine, an adenosine surrogate, was found to be particularly emissive and effectively deaminated by adenosine deaminase. Competitive studies with adenosine deaminase with each analogue in combination with native adenosine showed preference for the native substrate while still deaminating the isothiazolo analogues. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/eb/SC-008-C6SC05354H.PMC5380116.pdf |
| Alternate Webpage(s) | https://pubs.rsc.org/en/content/articlepdf/2017/sc/c6sc05354h |
| Alternate Webpage(s) | http://pubs.rsc.org/en/content/articlepdf/2017/sc/c6sc05354h |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
