NDLI: Mixed species biofilms of Candida albicans and Staphylococcus epidermidis.

Content Provider	Semantic Scholar
Author	Adam, Berit Baillie, George S. Douglas, Laura J.
Copyright Year	2002
Abstract	A simple catheter disk model system was used to study the development in vitro of mixed species biofilms of Candida albicans and Staphylococcus epidermidis, two organisms commonly found in catheter-associated infections. Two strains of S. epidermidis were used: a slime-producing wild type (strain RP62A) and a slime-negative mutant (strain M7). In mixed fungal-bacterial biofilms, both staphylococcal strains showed extensive interactions with C. albicans. The susceptibility of 48-h biofilms to fluconazole, vancomycin and mixtures of the drugs was determined colorimetrically. The results indicated that the extracellular polymer produced by S. epidermidis RP62A could inhibit fluconazole penetration in mixed fungal-bacterial biofilms. Conversely, the presence of C. albicans in a biofilm appeared to protect the slime-negative staphylococcus against vancomycin. Overall, the findings suggest that fungal cells can modulate the action of antibiotics, and that bacteria can affect antifungal activity in mixed fungal-bacterial biofilms.
File Format	PDF HTM / HTML
DOI	10.1099/0022-1317-51-4-344
PubMed reference number	11926741
Journal	Medline
Volume Number	51
Issue Number	4
Alternate Webpage(s)	https://www.microbiologyresearch.org/docserver/fulltext/jmm/51/4/mjm5104.344.pdf?accname=guest&checksum=6305A7BF664337EAD5CE28E5E11413D8&expires=1556648941&id=id
Alternate Webpage(s)	http://www.microbiologyresearch.org/docserver/fulltext/jmm/51/4/mjm5104.344.pdf?accname=guest&checksum=56874A9E9F9077C375A82C6B25425406&expires=1541960113&id=id
Alternate Webpage(s)	https://www.microbiologyresearch.org/docserver/fulltext/jmm/51/4/mjm5104.344.pdf?accname=guest&checksum=D4721C9BF39EDDE26A3DD1945194A915&expires=1545891043&id=id
Alternate Webpage(s)	https://www.microbiologyresearch.org/docserver/fulltext/jmm/51/4/mjm5104.344.pdf?accname=guest&checksum=A0B6B1F22AAF880D73DF129543373D38&expires=1549569798&id=id
Alternate Webpage(s)	https://doi.org/10.1099/0022-1317-51-4-344
Journal	Journal of medical microbiology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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