A randomized, prospective comparison of allogeneic bone marrow and peripheral blood progenitor cell transplantation in the treatment of hematologic malignancies: an update.

Content Provider	Semantic Scholar
Author	Vigorito, Afonso Celso Júnior, J. F. Marques Aranha, Francisco Oliveira, Gislaine Barbosa Miranda, Eliana C. M. Souza, Carmino Antônio De
Copyright Year	2001
Abstract	Summary: We present the results of a prospective, randomised study comparing PBPC and BM focusing on engraftment, acute and chronic GVHD and survival. Forty patients with haematological malignancies received HLA-identical sibling BM (group A) or PBPC (group B). Evaluable patients were 19 (A) and 18 (B). Median age was 35 (17‐56) in A and 29.5 (9‐51) in B. Conditioning was mainly Bu-Cy2; GVHD prophylaxis was CSA-MTX. PBPC were harvested after 5 days of G-CSF 10 mg/kg/day. Median days for an ANC .0.5 3 10 9 /l was 18 (13‐30) in A and 16 (11‐25) in B (P = 0.10). Platelets .20 3 10 9 /l occurred at 117 (10‐ 40) in A and 112 (9‐36) in B (P = 0.01). The probability of >2 grade a-GVHD was 19% (A) and 27% (B) (P = 0.53). The probability of all grade c-GVHD was 70% with BM. In spite of the small number of patients in group B (PBPC), our data suggest the great majority of them will have c-GVHD (P = 0.08); extensive disease was present in 50 and 100%, respectively (P = 0.05). The estimates of overall survival for A and B at 1000 days are 51 and 47%, respectively (P = 0.67); DFS at 1000 days are 52 and 58%, respectively (P = 0.50). PBPC resulted in faster platelet engraftment. The incidence of acute and chronic GVHD was similar in both groups, but the severity of c-GVHD was higher with PBPC. No differences in survival and DFS have been observed to date.
File Format	PDF HTM / HTML
PubMed reference number	11418381
Journal	Medline
Volume Number	86
Issue Number	6
Alternate Webpage(s)	http://www.haematologica.org/content/haematol/86/6/665.full.pdf
Journal	Haematologica
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article