Loading...
Please wait, while we are loading the content...
Similar Documents
Balancing reversion of cytotoxic T-lymphocyte and neutralizing antibody escape mutations within human immunodeficiency virus type 1 Env upon transmission.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Peut, Viv Campbell, Shahan M. Gaeguta, Adriana Center, Rob J. Wilson, K. S. Alcântara, Sheilajen Fernandez, Caroline S. Purcell, Damian Kent, Stephen J. |
| Copyright Year | 2009 |
| Abstract | Human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) is subject to both neutralizing antibody (NAb) and CD8 T-cell (cytotoxic T-lymphocyte [CTL]) immune pressure. We studied the reversion of the Env CTL escape mutant virus to the wild type and the relationship between the reversion of CTL mutations with N-linked glycosylation site (NLGS)-driven NAb escape in pigtailed macaques. Env CTL mutations either did not revert to the wild type or only transiently reverted 5 to 7 weeks after infection. The CTL escape mutant reversion was coincident, for the same viral clones, with the loss of NLGS mutations. At one site studied, both CTL and NLGS mutations were needed to confer NAb escape. We conclude that CTL and NAb escape within Env can be tightly linked, suggesting opportunities to induce effective multicomponent anti-Env immunity. |
| File Format | PDF HTM / HTML |
| DOI | 10.1128/JVI.00599-09 |
| PubMed reference number | 19515763 |
| Journal | Medline |
| Volume Number | 83 |
| Issue Number | 17 |
| Alternate Webpage(s) | https://biomedicalsciences.unimelb.edu.au/__data/assets/pdf_file/0006/1761324/106PeutJVI2009.pdf |
| Alternate Webpage(s) | https://doi.org/10.1128/JVI.00599-09 |
| Journal | Journal of virology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
