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The contribution of poly(ADP-ribose)polymerase-1 activity in the nucleotide excision repair pathway
| Content Provider | Semantic Scholar |
|---|---|
| Author | King, Brenee S. |
| Copyright Year | 2012 |
| Abstract | Exposure to ultraviolet radiation (UVR) promotes the formation of UVR-induced, DNA helix distorting photolesions such as (6-4) pyrimidine-pyrimidone photoproducts (6-4 PPs) and cyclobutane pyrimidine dimers (CPDs). Effective repair of such lesions by the nucleotide excision repair (NER) pathway is required to prevent DNA mutations and chromosome aberrations. Poly(ADP-ribose)polymerase-1 (PARP-1) is a zinc-finger protein with well documented involvement in base excision repair (BER). PARP-1 is activated in response to DNA damage and catalyzes the formation of poly(ADP-ribose) subunits (PAR) that assist in the assembly of DNA repair complexes at sites of damage. In this dissertation, I present evidence for PARP-1 contributions to NER, extending the knowledge of PARP-1 function in DNA repair beyond the established role in BER. Silencing the PARP-1 protein or inhibiting PARP activity leads to retention of UVRinduced photolesions in vitro and in vivo. PARP activation following UVR exposure promotes association between PARP-1 and XPC, a central protein in lesion recognition in |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://digitalrepository.unm.edu/cgi/viewcontent.cgi?article=1065&context=biom_etds |
| Alternate Webpage(s) | https://digitalrepository.unm.edu/cgi/viewcontent.cgi?article=1065&context=biom_etds |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
