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Anti-inflammatory Approaches to Mitigate the Neuroinflammatory Response to Brain-Dwelling Intracortical Microelectrodes
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bedell, Hillary W. Capadona, Jeffrey R. |
| Copyright Year | 2018 |
| Abstract | Intracortical microelectrodes are used both in basic research to increase our understanding of the nervous system and for rehabilitation purposes through brain-computer interfaces. Yet, challenges exist preventing the widespread clinical use of this technology. A prime challenge is with the neuroinflammatory response to intracortical microelectrodes. This mini-review details immunomodulatory strategies employed to decrease the inflammatory response to these devices. Over time, broad-spectrum anti-inflammatory approaches, such as dexamethasone and minocycline, evolved into more targeted treatments since the underlying biology of the neuroinflammation was elucidated. This review also presents studies which examine novel prospective targets for future immunomodulatory targeting. |
| Starting Page | 15 |
| Ending Page | 21 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.29245/2578-3009/2018/4.1157 |
| PubMed reference number | 30854523 |
| Journal | Medline |
| Volume Number | 2 |
| Alternate Webpage(s) | http://www.immunologyresearchjournal.com/articles/antiinflammatory-approaches-to-mitigate-the-neuroinflammatory-response-to-braindwelling-intracortical-microelectrodes.pdf |
| Alternate Webpage(s) | https://doi.org/10.29245/2578-3009%2F2018%2F4.1157 |
| Journal | Journal of immunological sciences |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
