NDLI: Cardiac side population cells: moving toward the center stage in cardiac regeneration.

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Cardiac side population cells: moving toward the center stage in cardiac regeneration.

Content Provider	Semantic Scholar
Author	Unno, Kazumasa Jain, Mohit Laxmilal Liao, Ronglih
Copyright Year	2012
Abstract	Over the past decade, extensive work in animal models and humans has identified the presence of adult cardiac progenitor cells, capable of cardiomyogenic differentiation and likely contributors to cardiomyocyte turnover during normal development and disease. Among cardiac progenitor cells, there is a distinct subpopulation, termed "side population" (SP) progenitor cells, identified by their unique ability to efflux DNA binding dyes through an ATP-binding cassette transporter. This review highlights the literature on the isolation, characterization, and functional relevance of cardiac SP cells. We review the initial discovery of cardiac SP cells in adult myocardium as well as their capacity for functional cardiomyogenic differentiation and role in cardiac regeneration after myocardial injury. Finally, we discuss recent advances in understanding the molecular regulators of cardiac SP cell proliferation and differentiation, as well as likely future areas of investigation required to realize the goal of effective cardiac regeneration.
Starting Page	225
Ending Page	234
Page Count	10
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://circres.ahajournals.org/content/circresaha/110/10/1355.full.pdf?download=true
PubMed reference number	22581921v1
Alternate Webpage(s)	https://doi.org/10.1161/CIRCRESAHA.111.243014
DOI	10.1161/circresaha.111.243014
Journal	Circulation research
Volume Number	110
Issue Number	10
Language	English
Access Restriction	Open
Subject Keyword	Animal Model Artificial cardiac pacemaker Cardiomyopathies Cell Proliferation Myocardium Myocytes, Cardiac Natural regeneration Sinoatrial Node Stem cells dna binding
Content Type	Text
Resource Type	Article

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