NDLI: Fixed Combination Antiemetic: A Literature Review on Prevention of Chemotherapy-Induced Nausea and Vomiting Using Netupitant/Palonosetron

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Fixed Combination Antiemetic: A Literature Review on Prevention of Chemotherapy-Induced Nausea and Vomiting Using Netupitant/Palonosetron

Content Provider	Semantic Scholar
Author	Clark-Snow, Rebecca Anne Vidall, Cheryl Börjeson, Sussanne Jahn, Patrick
Copyright Year	2018
Abstract	BACKGROUND Prevention of chemotherapy-induced nausea and vomiting (CINV) can be improved with guideline-consistent use of antiemetics. However, adherence to antiemetic guidelines remains often insufficient. Therefore, new strategies that improve adherence are needed. OBJECTIVES To review the latest antiemetic guideline recommendations and provide an update on the use of NEPA, a fixed combination antiemetic composed of the neurokinin-1 receptor antagonist (RA) netupitant and the 5-hydroxytryptamine-3 RA palonosetron (Akynzeo®). METHODS Analysis of the literature was performed, including guidelines, published literature, congress data on NEPA, and relevant articles on CINV. FINDINGS Nurses are in a unique position to promote guideline-consistent antiemetic prophylaxis and are central in the education of patients and caregivers. Thus, nurses’ continuous education on antiemetic treatments is key for the prevention and management of CINV. NEPA offers a simplified antiemetic therapy with the potential to increase guideline adherence.
Starting Page	E52
Ending Page	E63
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://cjon.ons.org/file/40586/download
Alternate Webpage(s)	https://cjon.ons.org/file/44546/download
Alternate Webpage(s)	https://ebooks.ons.org/file/44546/download
PubMed reference number	29547597v1
Alternate Webpage(s)	https://doi.org/10.1188/18.CJON.E52-E63
DOI	10.1188/18.CJON.E52-E63
Journal	Clinical journal of oncology nursing
Volume Number	22
Issue Number	2
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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