Effects of [des-Tyr-D-Phe3]beta-casomorphin (2–5) on sleep pattern in rats

Content Provider	Semantic Scholar
Author	Schulz, Stefan Diedrich, Michael Wetzel, W. Matthies, Hansju¨rgen
Copyright Year	1991
Abstract	The effects of the antidepressant-like acting peptide [des-Tyr-D-Phe3]beta-casomorphin(2-5) (Pro-D-Phe-Pro-Gly, BCH-325) on sleep were studied in rats. The rats received subcutaneous injections of BCH-325 in acute experiments (doses: 4, 20, 100, 500 and 2500 nmol/kg) and in a 10-day chronic experiment (50 nmol/kg/day). Acute administration of 20 and 100 nmol/kg enhanced wakefulness, 500 and 2500 nmol/kg enhanced paradoxical sleep, and 4 nmol/kg had no effect. Chronic administration resulted in an increase of paradoxical sleep during the first 5 days of drug treatment. Thus the sleep effects of BCH-325 differ from those of typical antidepressants and other psychotropic drugs.
Starting Page	893
Ending Page	896
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/0196-9781(91)90153-G
PubMed reference number	1788151
Journal	Medline
Volume Number	12
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/019697819190153G
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/019697819190153G?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0196-9781%2891%2990153-G
Journal	Peptides
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article