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Activités biologiques du Seigle et du Sorgho chez le rat « Wistar » rendu diabétique par la Streptozotocine
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mami, Épouse Soualem Zoubida |
| Copyright Year | 2015 |
| Abstract | Changing eating habits in recent years has led to the emergence of so-called civilization diseases; inter alia diabetes mellitus which is characterized by a common hyperglycemia caused by a deficit in insulin secretion or a cellular resistance to insulin. Some dieto-therapeutic approaches favor the consumption of cereal products in the most complete form possible. Sorghum (Sorghum bicolor L.), a well known species as a major source of polyphenols, is the fifth most important cereal crop grown in the world, after wheat, rice, corn and barley. Rye (Secale cereal L.) came quite late in agriculture, at least as cultivation in itself. These two secondary cereals are studied here because they possess therapeutic properties, and have been little investigated, compared to other cereals, such as wheat or barley. This work aims at testing the effect of phenolic extracts of the two cereals on the in vitro antioxidant capacity, and then verifying the effectiveness of the experimental diets, prepared with whole grains, on the correction of hyperglycemia, dyslipidemia and on oxidative stress markers associated with diabetes in Wistar rats. The phytochemical analysis performed on white sorghum and rye revealed the presence of a higher content of sugar (57.75 %) and protein (13.56 %) for rye, compared to white sorghum which presents high levels of polyphenols (313 μ / g), fat (4.67 %) and fiber (21 %). Analysis of oil from white sorghum and rye, using gas chromatography (GC), showed a high content in unsaturated fatty acids, mainly linoleic acid, estimated to 42.28 % and 7.5%, respectively. Evaluation of in vitro antioxidant power by colorimetric methods (DPPH, FRAP, βcarotene) revealed that the phenolic extracts of white sorghum have a higher antioxidant activity compared to that of rye. Moreover, the in vivo study of the antihyperglycemic and antioxidant properties of the two experimental diets, in Wistar rats made diabetic, showed that diabetic rats, under sorghum diet for four weeks, exhibited a significant decrease in blood sugar; it reached 53.95% at the end of the experiment, hence their blood sugar rate gets close to that of normoglycemics. White Sorghum showed a significant decrease in intracellular lipid peroxidation on one hand; on the other hand, it increased the activity of glutathione peroxidase, glutathione reductase and vitamin C. In conclusion, these results deserve a deeper study on additional work, by combining the two cereals into one diet to associate sorghum polyphenols, which have an interesting antioxidant power, with soluble fibers (β-glucan) of rye which has a remarkable antihyperglycemic effect, to prevent or mitigate the deleterious effect of diabetes and its complications. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://dspace.univ-tlemcen.dz/bitstream/112/8356/1/mami.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
