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Combining etanercept with traditional agents in the treatment of psoriasis: a review of the clinical evidence.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Foley, Peter Quirk, Catherine Sullivan, John Russell Dolianitis, Con Hack, Stephen Paul Thirunavukkarasu, Krishan Cooper, Alisa Joy |
| Copyright Year | 2010 |
| Abstract | Psoriasis is a chronic, systemic inflammatory disorder manifesting primarily in skin and potentially in joints, frequently necessitating treatment with conventional systemic therapies, phototherapy or biological agents. Patients with moderate to severe disease suffer a diminished quality of life, experience significant comorbidities and have a higher mortality. Although traditional treatments are effective in the short-term, their use is often limited by concerns over long-term toxicity, including end-organ damage and risk of malignancy. Combination therapy is a commonly used approach and is often more effective than any single agent. Lower doses of two treatments in combination can also minimize potential side effects from a single agent at higher doses. Etanercept is a recombinant human tumour necrosis factor (TNF)α receptor (p75) protein fused with the Fc portion of IgG1 that binds to TNFα. This article reviews the evidence on the efficacy and safety of etanercept in combination with methotrexate, acitretin, narrowband UVB and cyclosporin. The largest body of evidence assesses the combination with methotrexate, although evidence is available for the other combinations. Data suggest that although highly effective as monotherapy, etanercept in combination with a conventional systemic agent can enhance efficacy and allow drug sparing. Potentially, the combination may also result in faster treatment responses and permit safe transitioning from one systemic agent to another. Evidence to date suggests that these benefits can be achieved without significant additional toxicity, although long-term data on the efficacy and safety of the combination in psoriatic populations is limited and further evaluation is warranted. |
| Starting Page | 1455 |
| Ending Page | 1460 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://s2.e-monsite.com/2010/04/04/36886827cooper-j-eur-acad-dermatol-v-2010-mars-pdf.pdf |
| PubMed reference number | 20337816v1 |
| Alternate Webpage(s) | https://doi.org/10.1111/j.1468-3083.2010.03613.x |
| DOI | 10.1111/j.1468-3083.2010.03613.x |
| Journal | Journal of the European Academy of Dermatology and Venereology : JEADV |
| Volume Number | 24 |
| Issue Number | 10 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acitretin Adverse reaction to drug Biological Factors Combined Modality Therapy Cyclosporine Dental Plaque Etanercept Manuscripts Methotrexate Neoplasms Patients Phototherapy Psoriasis Recombinants Review [Publication Type] Therapeutic procedure Tumor Necrosis Factors Ultraviolet B radiation benefit ezetimibe / Simvastatin inflammatory disease |
| Content Type | Text |
| Resource Type | Article |
