Loading...
Please wait, while we are loading the content...
Similar Documents
Alpha-melanocyte-stimulating hormone reduces endotoxin-induced liver inflammation.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chiao, H. Foster, Simon Edward Thomas, Rusha Lipton, J. Star, Robert A. |
| Copyright Year | 1996 |
| Abstract | Alpha-Melanocyte-stimulating hormone (MSH) is a potent anti-inflammatory agent in many models of inflammation, suggesting that it inhibits a critical step common to different forms of inflammation. We showed previously that alpha-MSH inhibits nitric oxide (NO) production in cultured macro-phages. To determine how alpha-MSH acts in vivo, we induced acute hepatic inflammation by administering endotoxin (LPS) to mice pretreated with Corynebacterium parvum, alpha-MSH prevented liver inflammation even when given 30 min after LPS administration. To determine the mechanisms of action of alpha-MSH, we tested its influence on NO, infiltrating inflammatory cells, cytokines, and chemokines. Alpha-MSH inhibited systemic NO production, hepatic neutrophil infiltration, and increased hepatic mRNA abundance for TNF alpha, and the neutrophil and monocyte chemokines (KC/IL-8 and MCP-1). We conclude that alpha-MSH prevents LPS-induced hepatic inflammation by inhibiting production of chemoattractant chemokines which then modulate infiltration of inflammatory cells. Thus, alpha-MSH has an effect very early in the inflammatory cascade. |
| File Format | PDF HTM / HTML |
| DOI | 10.1172/JCI118639 |
| PubMed reference number | 8621792 |
| Journal | Medline |
| Volume Number | 97 |
| Issue Number | 9 |
| Alternate Webpage(s) | http://dm5migu4zj3pb.cloudfront.net/manuscripts/118000/118639/JCI96118639.pdf |
| Alternate Webpage(s) | https://doi.org/10.1172/JCI118639 |
| Journal | The Journal of clinical investigation |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
