NDLI: Colonic carcinoma microenvironment : immunohistochemical frequency and distribution of CD 3 , CD 8 , FOXP 3 infiltrating T lymphocytes

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Colonic carcinoma microenvironment : immunohistochemical frequency and distribution of CD 3 , CD 8 , FOXP 3 infiltrating T lymphocytes

Content Provider	Semantic Scholar
Author	Camelia, Croitoru Daniela, Jitaru Eliza, Simona Irina-Draga, Runtu Florin, Zugun Eloae Carmen, Cozmei Cristina, Rniceriu Anca, Vrânceanu Eugen, Carasevici
Copyright Year	2011
Abstract	Cancer pathogenesis is fundamentally dependent on t umor cell interactions with microenvironmental components. These interactions may either restrain umor progression or promote it. Inflammatory and i mmune stromal cell component, particularly lymphocytic re actions, plays decisive roles at different stages o f tumor development by generating a microenvironment that cou ld be supportive for growth and invasion and/or dev elopment of anti-tumor response. It is well recognized that cytotoxic CD8 T and regulatory FOXP3 + lymphocytes constitute important effector mechanisms of tumor i mmune surveillance. However, their potential progno stic influence in colorectal cancer remains controversial. We assessed infiltration of CD3 , CD8, and FOXP3 T lymphocytes within tumor tissue, invasive front, ad vancing tumor margin and normal colonic tissue of 6 9 colon tumors and correlated their distribution with clini cal stage. Our study shows that tumor stage progres sion associate a stromal traffic of T lymphocytes and positi ning depending on development of the malignant pro cess and suggests a complex diversity of cellular interplay in the frame of cancer microenvironment.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://rrml.ro/articole/2010/2010_4_1.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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