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Cochlear damage changes the distribution of vesicular glutamate transporters associated with auditory and nonauditory inputs to the cochlear nucleus.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zeng, Chunhua Nannapaneni, Nishant Zhou, Jianxun Hughes, Larry F. Shore, Susan Louise |
| Copyright Year | 2009 |
| Abstract | Integration of multimodal information is essential for understanding complex environments. In the auditory system, multisensory integration first occurs in the cochlear nucleus (CN), where auditory nerve and somatosensory pathways converge (Shore, 2005). A unique feature of multisensory neurons is their propensity to receive cross-modal compensation after deafening. Based on our findings that the vesicular glutamate transporters, VGLUT1 and VGLUT2, are differentially associated with auditory nerve and somatosensory inputs to the CN, respectively (Zhou et al., 2007), we examined their relative distributions after unilateral deafening. After unilateral intracochlear injections of kanamycin (1 and 2 weeks), VGLUT1 immunoreactivity (ir) in the magnocellular CN ipsilateral to the cochlear damage was significantly decreased, whereas VGLUT2-ir in regions that receive nonauditory input was significantly increased 2 weeks after deafening. The pathway-specific amplification of VGLUT2 expression in the CN suggests that, in compensatory response to deafening, the nonauditory influence on CN is significantly enhanced. One undesirable consequence of enhanced glutamatergic inputs could be the increased spontaneous rates in CN neurons that occur after hearing loss and that have been proposed as correlates of the phantom auditory sensations commonly called tinnitus. |
| Starting Page | 25 |
| Ending Page | 34 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.jneurosci.org/content/jneuro/29/13/4210.full.pdf |
| PubMed reference number | 19339615v1 |
| Alternate Webpage(s) | https://doi.org/10.1523/JNEUROSCI.0208-09.2009 |
| DOI | 10.1523/jneurosci.0208-09.2009 |
| Journal | The Journal of neuroscience : the official journal of the Society for Neuroscience |
| Volume Number | 29 |
| Issue Number | 13 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | CNS disorder Cell Nucleus Cochlear Nerve Cochlear nucleus structure Cochlear structure Glutamic Acid Hearing problem Kanamycin Membrane Transport Proteins Phantoms, Imaging Vesicular Glutamate Transport Proteins hearing impairment immunoreactivity |
| Content Type | Text |
| Resource Type | Article |
