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Conditioned c-Fos in mouse NTS during expression of a learned taste aversion depends on contextual cues
| Content Provider | Semantic Scholar |
|---|---|
| Author | Swank, Michael W. |
| Copyright Year | 2000 |
| Abstract | c-Fos expression in the nucleus tractus solitarius (NTS) of the rat has been found to follow administration of a variety of pharmacologically diverse unconditioned stimuli (US), and it has been proposed that NTS is a critical structure in transduction of the US during taste aversion learning. Before conditioning, the conditioned stimulus (CS) taste does not induce c-Fos in NTS, but following pairing of the CS and US, subsequent CS presentation induces c-Fos in NTS. Although it has been suggested that the shift in the c-Fos response following conditioning represents a molecular correlate of taste aversion learning, i.e. the formerly neutral CS now predicts the toxicity associated with the US, the data presented here suggest a more cautious interpretation of c-Fos expression in NTS. In mice, post-conditioning c-Fos expression to the CS depends on contextual cues: when conditioning and testing occur in a novel environment, CS saccharin causes an increase in c-Fos expression, and when conditioning and testing occur in the home cage, CS saccharin produces a decrease in c-Fos expression relative to controls. Furthermore, we show that merely placing an animal into a novel environment is sufficient to drive c-Fos expression in NTS. These data suggest that c-Fos expression in NTS can be driven by a number of different stimuli and conditions, and that these responses may depend on context-dependent activation of forebrain structures shown to drive conditioned c-Fos expression in NTS. |
| Starting Page | 138 |
| Ending Page | 144 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0006-8993(00)02101-6 |
| PubMed reference number | 10799678 |
| Journal | Medline |
| Volume Number | 862 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0006899300021016 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0006899300021016?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0006-8993%2800%2902101-6 |
| Journal | Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
