NDLI: Rapid detection of adulterated drugs in herbal dietary supplements by wooden-tip electrospray ionization mass spectrometry

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Rapid detection of adulterated drugs in herbal dietary supplements by wooden-tip electrospray ionization mass spectrometry

Content Provider	Semantic Scholar
Author	Huang, Yingyan Zhang, Gaofei Zhang, Liyang Wang, Tiejie Yao, Zhong-Ping
Copyright Year	2016
Abstract	Adulteration of herbal dietary supplements with unlabelled drugs is illegal and can lead to serious health problems in consumers. In this study, wooden-tip electrospray ionization mass spectrometry (WT-ESI-MS) was developed for rapid detection of adulterated drugs in three categories of herbal dietary supplements, namely tranquilizer, aphrodisiac and weight-loss products. Samples were directly taken by using pre-wetted wooden tips and analyzed by WT-ESI-MS, with the drug identities confirmed by MS/MS spectra. Furthermore, a high-throughput WT-ESI-MS method was developed to allow automated WT-ESI-MS and MS/MS analysis of herbal dietary supplement samples with an analysis speed of ∼15 seconds per sample. The limits of detection of typical drugs were found to be at the ng g−1 level using the WT-ESI-MS method. In this study, 33 commonly adulterated drugs were investigated and a spectral database containing the ESI-MS and ESI-MS/MS spectra of these drug standards was established. A total of 144 herbal dietary supplements were analyzed and the results were compared with those obtained by using high performance liquid chromatography. These results demonstrated a simple and comprehensive approach for rapid detection of adulterated drugs in herbal dietary supplements.
Starting Page	6840
Ending Page	6846
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1039/C6AY01735E
Volume Number	8
Alternate Webpage(s)	http://ira.lib.polyu.edu.hk/bitstream/10397/64527/1/c6ay01735e.pdf
Alternate Webpage(s)	http://www.rsc.org/suppdata/c6/ay/c6ay01735e/c6ay01735e1.pdf
Alternate Webpage(s)	https://doi.org/10.1039/C6AY01735E
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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