NDLI: Direct Organocatalytic Enantioselective α-Aminomethylation of Ketones.

Content Provider	Semantic Scholar
Author	Ibrahem, Ismail Zou, Weibiao Casas, Jesús Sundén, Henrik Córdova, Armando
Copyright Year	2006
Abstract	The scope and limitations of the direct organocatalytic asymmetric a-aminomethylation of ketones are disclosed. The prolinecatalyzed classical Mannich reactions between unmodified ketones, aqueous formaldehyde and aromatic amines furnished the desired Mannich bases in high yield with up to O99% ee. Moreover, methyl alkyl ketones were regioselectively a-aminomethylated at the methylene carbon affording the corresponding Mannich products with up to O99% ee. In addition, the proline-catalyzed one-pot threecomponent reaction between p-anisidine, aqueous formaldehyde and 4,4-dimethyl-2-cycloxehen-1-one furnished the corresponding bicyclic aza-Diels–Alder adduct with O99% ee. q 2005 Elsevier Ltd. All rights reserved.
File Format	PDF HTM / HTML
DOI	10.1002/chin.200621072
Volume Number	37
Alternate Webpage(s)	http://www.do.ufgd.edu.br/nelsondomingues/apresenta%C3%A7%C3%A3o%20aline.pdf
Alternate Webpage(s)	https://doi.org/10.1002/chin.200621072
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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