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Cinchona alkaloid -based phosphoramide catalyzed highly enantioselective Michael addition of unprotected 3-substituted oxindoles to nitroolefins
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ding, Miao Zhou, Feng Liu, Yun-Lin Wang, Cui-Hong Zhao, Xiaoli Zhou, Jian |
| Copyright Year | 2011 |
| Abstract | A newly developed cinchonidine-derived phosphoramide 6b, simple and easily available, was identified as a powerful catalyst for the highly enantioselective Michael addition of both unprotected 3-aryl and 3-alkyloxindoles to β-substituted nitroalkenes to furnish the C3 quaternary stereogenic carbon center with an adjacent tertiary stereocenter in up to 21 : 1 diastereoselectivity and up to 99% enantioselectivity. |
| Starting Page | 2035 |
| Ending Page | 2039 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C1SC00390A |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/sc/c1/c1sc00390a/c1sc00390a.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/C1SC00390A |
| Volume Number | 2 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |