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Self-assembly and mineralization of peptide-amphiphile nanofibers.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hartgerink, Jeffrey D. Beniash, Elia Stupp, Samuel I. |
| Copyright Year | 2001 |
| Abstract | We have used the pH-induced self-assembly of a peptide-amphiphile to make a nanostructured fibrous scaffold reminiscent of extracellular matrix. The design of this peptide-amphiphile allows the nanofibers to be reversibly cross-linked to enhance or decrease their structural integrity. After cross-linking, the fibers are able to direct mineralization of hydroxyapatite to form a composite material in which the crystallographic c axes of hydroxyapatite are aligned with the long axes of the fibers. This alignment is the same as that observed between collagen fibrils and hydroxyapatite crystals in bone. |
| File Format | PDF HTM / HTML |
| DOI | 10.1126/science.1063187 |
| PubMed reference number | 11721046 |
| Journal | Medline |
| Volume Number | 294 |
| Issue Number | 5547 |
| Alternate Webpage(s) | https://patentimages.storage.googleapis.com/0e/1f/3d/cc596e826cec88/US20040018961A1.pdf |
| Alternate Webpage(s) | https://doi.org/10.1126/science.1063187 |
| Journal | Science |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Patent |
